CBD bioavailability formula

CBD bioavailability refers to the exact amount of CBD that will get into your bloodstream. It is certainly helpful to work on strategies that will increase CBD bioavailability. When choosing a meal that will enhance the Bioavailability, it becomes necessary to examine each of them for the Bioavailability provisions.

The best consideration that will increase Bioavailability is ensuring that the carrier product is water-soluble. Solubility increases the chances of absorption because 90% of the human body is made of plasma; hence the benefits will be felt faster when the product is insoluble.

What is CBD Bioavailability?

CBD bioavailability is a measure of CBD effectiveness. CBD bioavailability answers the question “how much CBD does my body get?” When CBD is in your bloodstream, it has to compete with a large amount of CBD that is already there. Ingested CBD, whether from an oil capsule or from dried cannabis flower, must pass through the liver before it enters the bloodstream.

CBD and CBD-like substances in the liver compete with CBD and CBD-like substances in CBD for access to CBD receptor sites throughout the body. The CBD that survives this process, known as “first pass metabolism,” is available to affect processes throughout your body.

The CBD that doesn’t survive first pass metabolism is not available. CBD bioavailability varies from person to person, and CBD products vary in the amount CBD that survives first pass metabolism.

Processing of CBD by the Body

CBD products are now available in a wide array, and the most common ones are balms, tinctures, oil, sprays, and capsules. Every manufacturer defines the benefits you get when you take the CBD product in the form they make. Hold on, and let’s focus on the popular CBD forms that you won’t miss in the market.


When you are using a CBD edible, it implies that you will consume it just like any other food, and you will have to wait for digestion to experience its first effects. The product goes through processing in the digestive system and keeps moving until it arrives at the liver, where metabolism occurs. The CBD will get into the bloodstream after metabolism.

You might be wondering why the CBD bioavailability of tinctures is higher than that for drinks, gummies, and capsules. The edibles will go through a long digestion route, while tinctures will be absorbed directly into the bloodstream.



Vaping is the most convenient way to ingest CBD into your bloodstream if you need instant feedback. If you are looking for a bioavailable way to take CBD, you can be certain about 10 to 60% when using the method. Vaping is the most effective way to manage moods, sleep, and stress. When Vaping, users should know the right heat that will allow effective vaporization of CBD.

CBD bioavailability is optimized through Vaping, but you should be careful not to overheat the CBD, lest it vaporizes into benzenes that might be hazardous.

The CBD Oil Drops

Oil drops

CBD oils are the most popular CBD products with high chances of Bioavailability. Many people consume CBD oil sublingually. It entails placing the oil under the tongue and holding it for 60 to 90 seconds to experience the impact.

Consuming the products sublingually ensures that the products land up in your bloodstream faster, for it bypasses the digestive system that will have delayed the whole process. Not that its Bioavailability may not surpass that of Vaping.


The topical application of CBD products happens to be the most popular practice among athletes. The question of CBD and its Bioavailability now comes in because the creams, balms, and salves are everywhere. The absorption of CBD here gets through the skin and is transferred through the pores towards the dermis. The dermis has CB2, and TRPV1 receptors in the periphery help enhance the effectiveness of the CBD. The topical is effective in alleviating the discomfort in muscles.

How to Increase the Bioavailability of CBD?

There are many ways to improve the Bioavailability of CBD. The article shall focus on how we can harness the Bioavailability of CBD.

  • Making CBD infused snacks

Creating CBD snacks rich in fats and fatty acids makes the CBD Bioavailable because they can break down large molecules of CBD into smaller particles, making it more absorbable. Hemp seed, olive oil, almond, and coconuts oil are the most convenient fats that work well with CBD.

  • Using nanotechnology and emulsification

Emulsification is a nanotechnological process that will break down large CBD molecules into smaller ones. The process uses an oil or water-based product. Such a process micronized the CBD particles improving their Bioavailability.

  • Using supplemental herbs

To boost your CBD bioavailability, consuming it with supplemental compounds with research backing for effectiveness is necessary. They include chamomile flowers, spicy peppers, and peperine. The supplemental herbs may influence metabolism and other body processes. Peperine, for instance, acts against the metabolic process, a process that resembles that of turmeric and pepper. They trigger apoptosis reversing the effects of drug resistance of the cancer cells.

  • The use of terpenes

Using terpenes is also another way to harness the Bioavailability of CBD. They are fatty oils that will naturally occur in all plants. Terpenes create flavors and fragrances in fruits and herbs. They are also available in hemp and will be extracted along with the CBD. They work in synergy to accord the benefits we all seek when consuming CBD products.

The common examples of terpenes that increase CBD bioavailability are limonene, alpha-pinene, menthol, and myrcene. Others are linalool and beta-caryophyllene. The terpenes are good when you are seeking sedative benefits. Lavender, for instance, boosts your mood and sleep, may also alleviate discomfort, and relieves stress.

Factors Which Can Influence Bioavailability

While the data points shown above are important as average indicators and should be kept in mind, other localized elements can influence how CBD is absorbed into the bloodstream. Pre-existing medical conditions: CBD has been shown to interact with the liver.

According to one study, individuals with a lower-than-average liver function are more likely to absorb CBD at a slower rate. If you intend to start the CBD, you must speak to the medical provider, especially under medications, before starting.

According to a study by the University of Minnesota, CBD is absorbed more effectively when ingested with a high-fat meal and up to four times more when consumed when fasted. This implies that taking the CBD like the tinctures and oils may accord more possible results than consuming edibles through digestion.

The Bottom Line

The bottom line here is increasing the CBD bioavailability that increases CBD amounts that reach the bloodstream. It should be noted that taking CBD, say 10mg, does not imply that the whole 10mg will get into the bloodstream because some are lost through digestion, spillage, and other ways. The CBD bioavailability topic attempts to expound on how people can improve their CBD intake.

By John H. Den

John H. Den dedicates all his time to educate people on why they should not suffer anxiety, stress, and depression when CBD can help them. He writes many articles about CBD and how to choose the best brands with high potencies. His work is an inspiration to many people, and he now receives many contracts from the top CBD brands because of his in-depth knowledge.

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