As time going, newer effects of CBD and other cannabinoids are coming out. All the compounds in cannabis plants contribute more or less to wellness and health healing, just like players in a team. So, the win is not so far for the team- cannabis. But many of us don’t know about the synergistic work- the entourage effect of CBD, THC and other cannabinoids.
So, what is the entourage effect? This article will help a lot to know the CBD entourage effect, entourage effect and cannabinoids, terpenes. Again, how the entourage effect works, what it feels like, and the holistic benefits of CBD entourage effect.
What Is The Entourage Effect?
The term Entourage Effect describes the enhanced effects of cannabinoids, the chemical compounds of cannabis plants like CBD. An effect is created when multiple compounds work together synergistically rather than alone. That synergistic effect is regarded as the Entourage Effect.
The entourage effect is a theory, which may entirely change depending on how you consume CBD going forward. The theory suggests that CBD is more effective when taken with other cannabinoids at the same time. The entourage effect is nothing but the synergistic relationship between the naturally present active chemical compounds in the cannabis plant including,
- The two major cannabinoids (CBD and THC)
- The “minor” cannabinoids present in much smaller quantities, such as CBG, CBC, CBN, and the 108 others
- Flavonoids, minerals, fatty acids, vitamins, and other phytochemicals
By working synergistically, these compounds create greater benefits than those that CBD or THC does by themselves. The entourage effect started in 1998 with the findings of Professors Raphael Mechoulam and Shimon Ben-Shabat that the Endocannabinoid System demonstrated an “entourage effect.” They witnessed then that the cannabis plant compounds significantly enhanced the activity of the receptors.
The receptors interacting with our Endocannabinoid System play a vital role in regulating and balancing many body processes, like sleep cycles, immune response, communication between cells, memory, and more. In 2001, two highly famous researchers John McPartland and Ethan Russo, published “Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts.”
That research paper further examined what Professors Mechoulam and Ben-Shabat claimed on “how cannabinoids act with secondary compounds, such as terpenes and flavonoids.” They found supporting evidence that extracts rich in cannabinoids and terpenes uplifted pharmacological activities strengthening and broadening clinical applications and enhancing the therapeutic index.
Cannabinoids and The Entourage Effect
All the compounds in cannabis work synergistically. While working together, they produce a better effect than when taken alone. Research shows that cannabinoids work better with a combination of cannabinoids, terpenes, and flavonoids compared to a CBD product with fewer compounds or even just pure CBD.
The main active compounds in cannabis are cannabinoids, which are the main contributors to the entourage effect. Although researchers have found over 113 different cannabinoids in cannabis, tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most famous for their high prevalence.
Terpenes and The Entourage Effect
Terpenes are aromatic molecules that grow in a variety of plants. For example, the terpene pinene has the fragrance of pine trees. Much like the cannabinoids, there are well over 100 terpenes in cannabis plants, including myrcene, caryophyllene, linalool, limonene, and pinene. The composition of terpenes plays a big role in differentiating strains of cannabis. The terpenes indeed shine and elevate their effectiveness when coupled with cannabinoids.
Several conditions have been studied combined with the entourage effect. One 2011 review of studies in the British Journal of Pharmacology identified that taking terpenes and phytocannabinoids together might be more beneficial for:
- Fungal infection
Research from 2018 determined that certain flavonoids and terpenes may provide neuroprotective and anti-inflammatory effects. Researchers disclosed that those compounds could enhance CBD’s therapeutic potential.
How Does The Entourage Effect Work?
There is much more to the cannabis plant as a whole than just CBD and THC each. The plant has dozens of different active cannabinoids, each having its unique properties. Although CBD is the most beneficial from the wellness viewpoint, the support of other cannabinoids can typically increase the compound’s performance and ability that can positively impact the ECS. For this, many people are switching to the full spectrum CBD as a part of their daily wellness routine.
Entering the body, the varied cannabinoid content in full-spectrum CBD can help to maximize the potency of the cannabis plant. When multiple cannabinoids are integrated, their medicinal effects may be altered or enhanced. Then their flavors and psychoactive capacities may also be affected and create different products with varying characteristics.
Researchers believe that the entourage effect emerges from the interactions between cannabinoids and between terpenes and cannabinoids. The group dynamics of the entourage effect may potentially create emergent properties absent in pure THC or CBD. Many people working closely with cannabis believe that the entourage effect can drastically increase the medicinal value of THC and CBD, either by magnifying their effects or by expanding their therapeutic applications.
Note that the therapeutic effects of cannabis compounds are created from their capacity to bind with naturally occurring endocannabinoid receptors not only in the brain but also throughout the central nervous system. Our endocannabinoid system is designed to link with endogenous cannabinoids produced by the body. But the cannabinoids found in cannabis plants can efficiently bind with the cannabinoid receptors.
What Does The Entourage Effect Feel Like?
The entourage effect is a strain. This strain will cause the user to feel good but not as strong to get them ‘high’ like the THC content. CBD counteracts the anxiety-inducing effects of THC, which helps the user feel relaxed and mellowed out.
Holistic Benefits of CBD Entourage Effect
You can find the beneficial compounds of CBD’s entourage effect rarely existing in their isolated form in nature. They’re combined with hundreds of other active compounds.
If you want to enjoy the holistic wellness benefits of CBD entourage effects, it’s best to use full-spectrum or broad-spectrum CBD products.
The Bottom Line
Having an in-depth knowledge of the content of the entourage effect is crucial for being able to distinguish between different forms of CBD. If you can know exactly what you’re buying, you can be able to attain greater benefits.
However, you should know that the entourage effect is still a theory because much more research is necessary into the cannabis plant and its chemical composition before we know the full extent of its potential medical benefits.